Cell
Volume 141, Issue 2, 16 April 2010, Pages 280-289
ArticleMitochondrial Fusion Is Required for mtDNA Stability in Skeletal Muscle and Tolerance of mtDNA Mutations
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Graphical Abstract
Highlights
► Mice lacking mitochondrial fusion in skeletal muscle exhibit mitochondrial myopathy ► Fusion is essential for maintenance of mitochondrial DNA (mtDNA) levels ► Loss of mitochondrial fusion results in increased mtDNA mutations ► Fusion protects mitochondrial respiration in cells with high loads of mutated mtDNA
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These authors contributed equally to this work
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Present address: Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA
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