Mechanisms of asthma and allergic inflammationA common mitochondrial haplogroup is associated with elevated total serum IgE levels
Section snippets
Human subjects
The Institutional Review Boards of the Brigham and Women's Hospital and of the other Childhood Asthma Management Program (CAMP) study centers approved this study. Informed assent and consent were obtained from the study participants and their parents to collect DNA for genetic studies.
Population
The CAMP Study is a multicenter North American clinical trial designed to investigate the long-term effects of inhaled anti-inflammatory medications in 1041 children with mild-to-moderate asthma.25, 26 Enrollment
Mitochondrial single nucleotide polymorphism genotyping
Torroni et al21 previously defined the common mitochondrial haplogroups among Western Europeans, describing 9 common haplogroups with frequencies >.01. For this initial survey of mitochondrial genetic variation in relation to atopic phenotypes, we selected 8 single nucleotide polymorphisms (SNPs) with minor allele frequencies of at least 0.05 that in combination efficiently tag these common European mitochondrial haplogroups.23 Genotype completion rates were at least 95% at all 8 loci (Table I
Discussion
Despite substantial epidemiologic evidence supporting maternal inheritance of asthma and atopy, this is the first report exploring the relationship between these phenotypes and mitochondrial genomic sequence variation. Our preliminary evidence shows an association between common European mitochondrial haplogroups and atopic phenotypes in a cohort of children with mild to moderate asthma. The common mitochondrial haplogroup U, present in 11% of the cohort, was associated with significantly
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2018, Biomedicine and PharmacotherapyCitation Excerpt :High concentrations of ozone are associated with the increases in mortality, hospitalizations, and emergency-department visit rates of asthmatics [5–7]. Notably, compared with non-asthmatic patients, the decrements of forced expiratory volume in one second(FEV1) and the increases of airway responsiveness are more significant in asthmatics following high concentration ozone exposure (0.4 ppm, 2 h) [8,9]. Greater ozone-induced decrements are found in asthmatics who had lower baseline FEV1 divided by forced vital capacity (FVC) and lower baseline FEV1 [10,11].
Mitochondrial biology and medicine
2018, Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics: FoundationsAn exploratory analysis of mitochondrial haplotypes and allogeneic hematopoietic cell transplantation outcomes
2015, Biology of Blood and Marrow TransplantationCitation Excerpt :This procedure was performed for all 8 SNPs separately. After an allele call for all 8 SNPs for a single sample, 1 of the 11 mthaps was determined using a checkerboard approach [29]. A total of 29 samples (19 patient, 10 donor) had an mthap that did not correspond to 1 of the 11 European groups defined by the above primer sets and were labeled as “other.”
Pathogenesis of allergic diseases and implications for therapeutic interventions
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The CAMP Genetics Ancillary Study was supported by the National Heart, Lung, and Blood Institute (NHLBI), NO1-HR-16049. Additional support for this research came from grants P50 HL67664 and T32 HL07427 from the National Institutes of Health and the NHLBI. B.A.R. is a recipient of a Mentored Clinical Scientist Development Award from the National Institutes of Health/NHLBI (K08 HL074193).
Disclosure of potential conflict of interest: C. A. Camargo, Jr, has consultant arrangements with Altana, Pfizer, AstraZeneca, Critical Therapeutics, Dey, Genentech, Novartis, GlaxoSmithKline, MedImmune, Merck, NuPharmx, Praxair, Respironics, Schering-Plough, and Sepracor and has received research support from AstraZeneca, Aventis Pasteur, Dey, GlaxoSmithKline, Janssen, MedImmune, Merck, Oridion, and Novartis. E. K. Silverman has consultant arrangements with GlaxoSmithKline; has received research support from GlaxoSmithKline; and has served on the speakers' bureau for GlaxoSmithKline, Wyeth, and Bayer. The rest of the authors have declared that they have no conflict of interest.