Elsevier

Transplantation Proceedings

Volume 36, Issue 8, October 2004, Pages 2359-2361
Transplantation Proceedings

Serum LECT2 level as a prognostic indicator in acute liver failure

https://doi.org/10.1016/j.transproceed.2004.07.007Get rights and content

Abstract

In the present study, we investigated the relationship between serum leukocyte cell-derived chemotaxin2 (LECT2) levels and liver function in patients with acute liver failure, and its use as a prognostic indicator. We studied six acute liver failure patients (two women, four men; 49.8 ± 20.7 years old) admitted to our hospital in 2002. These patients had diagnoses of fulminant hepatitis due to acute liver failure (1) from congestive heart failure; (2) from portal venous gas, and (3) from postoperative disseminated intravascular coagulation (DIC). We measured serum LECT2, GOT, and GPT levels, the last two being inversely proportionate to the serum LECT2 levels. When the serum GPT levels peaked, the serum LECT2 levels were the lowest. When the liver function recovered, serum LECT2 levels increased. Three of four patients died due to liver failure, one to congestive heart failure. Maximum serum LECT2 levels among the expired group were significantly lower than those among the alive group (0.96 ± 0.8 ng/mL vs 12.9 ± 4.3 ng/mL). Serum LECT2 levels may be a prognostic indicator of recovery from liver failure. The present study suggests that in clinical medicine LECT2 participates in regeneration after injury of hepatocytes.

Section snippets

Patients and methods

We studied six patients (two women, four men; 49.8 ± 20.7 years old) with acute liver failure who were admitted in the year 2002. Three patients had fulminant hepatitis with acute liver failure due to congestive heart failure, to portal venous gas, or to postoperative disseminated intravascular coagulation (DIC). We measured serum LECT2, GOT, and GPT levels. Serum LECT2 level was measured by human LECT2 ELISA system (Medical & Biological Laboratories (MBL) Co, Ltd, Niigata, Japan).

Results

Serum GPT and GOT levels were inversely proportionate to the LECT2 levels. When serum GPT levels peaked, the serum LECT2 levels were at a radius (Fig 1). When liver function recovered, serum LECT2 levels increased (Fig 2). Three of four patients died due to liver failure and the other one due to congestive heart failure. Maximum serum LECT2 levels among the decreased group (case 4, who died due to heart failure, was excepted) were significantly lower than those of the alive group (0.96 ± 0.8

Discussion

We describe the inverse proportion of serum LECT2 levels to liver injury during hepatic regeneration after adult LRDLT in both donor and recipient. The present studies demonstrated that serum LECT2 levels were influenced by hepatic regeneration in fulminant hepatitis in addition to changes following hepatectomy. Serum LECT2 levels may represent a prognostic indicator of recovery from liver failure. The present study suggested that in clinical medicine LECT2 participates in the regeneration

References (4)

  • S. Yamagoe et al.

    Immunol Lett

    (1996)
  • S. Yamagoe et al.

    Pathol Int

    (1998)
There are more references available in the full text version of this article.

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This work was supported by grant aid for Scientific Research from the Ministry of Education, Sciences, and Culture, Japan.

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