Serum LECT2 level as a prognostic indicator in acute liver failure
Section snippets
Patients and methods
We studied six patients (two women, four men; 49.8 ± 20.7 years old) with acute liver failure who were admitted in the year 2002. Three patients had fulminant hepatitis with acute liver failure due to congestive heart failure, to portal venous gas, or to postoperative disseminated intravascular coagulation (DIC). We measured serum LECT2, GOT, and GPT levels. Serum LECT2 level was measured by human LECT2 ELISA system (Medical & Biological Laboratories (MBL) Co, Ltd, Niigata, Japan).
Results
Serum GPT and GOT levels were inversely proportionate to the LECT2 levels. When serum GPT levels peaked, the serum LECT2 levels were at a radius (Fig 1). When liver function recovered, serum LECT2 levels increased (Fig 2). Three of four patients died due to liver failure and the other one due to congestive heart failure. Maximum serum LECT2 levels among the decreased group (case 4, who died due to heart failure, was excepted) were significantly lower than those of the alive group (0.96 ± 0.8
Discussion
We describe the inverse proportion of serum LECT2 levels to liver injury during hepatic regeneration after adult LRDLT in both donor and recipient. The present studies demonstrated that serum LECT2 levels were influenced by hepatic regeneration in fulminant hepatitis in addition to changes following hepatectomy. Serum LECT2 levels may represent a prognostic indicator of recovery from liver failure. The present study suggested that in clinical medicine LECT2 participates in the regeneration
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This work was supported by grant aid for Scientific Research from the Ministry of Education, Sciences, and Culture, Japan.