Chest
Clinical InvestigationsBronchiolitis Obliterans Organizing Pneumonia: Clinical Features and Differential Diagnosis
Section snippets
Patients and Materials
During a BOOP meeting held in Kyoto, Japan (1990), clinical data, chest roentgenographic and CT films, and pathologic materials obtained from patients diagnosed as having BOOP or being suspected of having BOOP by open lung biopsy, collected all over Japan, were discussed. Cases histopathologically diagnosed as BOOP according to Dr. Thomas V. Colby2 with unknown causes and not associated with other diseases were analyzed. Furthermore, the clinical features of 15 open lung biopsy specimens from
Clinical Data
There was no sexual predominance (Table 1), the incidence being similar between men and women. The mean age of the patients was in the mid 50s. Fifty-six percent of patients were nonsmokers, and 44 percent had a smoking history. There was no correlation between smoking status and BOOP.
Initial symptoms were cough (76 percent), fever (53 percent), and dyspnea (47 percent), and 94 percent of the patients had one, two, or all of these symptoms.
Crackles were heard at a high rate (79 percent),
Discussion
The clinical features of 34 Japanese patients with BOOP have been reported. These clinical findings are in agreement with those reported previously,3, 4, 5, 6, 7 and they are considered to be useful in the diagnosis of BOOP The diagnosis of BOOP has relied upon open lung biopsy, but the clinical diagnosis for management can be made when the case shows the above clinical features, and in which transbronchial lung biopsy has revealed the findings of proliferative bronchiolitis obliterans and
ACKNOWLEDGMENT
This report is a joint study of the following hospitals in Japan: Sapporo Medical College Hospital, Sapporo Horonan Hospital, Akita University Hospital, JR Tokyo General Hospital, Tokyo Antituberculosis Association Hospital, Tokai University Hospital, Hamamatsu Medical College Hospital. Hamamatsu Medical Center, Seirei Mikatagahara Hospital. Aichi Medical College Hospital, Fukui Red Cross Hospital, Shiga Medical College Hospital, Chest Disease Research Institute Hospital of Kyoto University,
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