Chest
Committee ReportCriteria for the Assessment of Reversibility in Airways Obstruction: Report of the Committee on Emphysema American College of Chest Physicians
Section snippets
Clinical Data
Measurable reversibility is likely if the patient gives a history of considerable variability in shortness of breath demonstrated, for instance, by excellent exercise tolerance sometimes and marked limitation by dyspnea at other times. This is particularly significant when the increased dyspnea occurs in association with wheezing, especially when there is exposure to possible allergens. The history is important if the patient is seen during symptom-free period when examination of the chest and
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Post-bronchodilator Reversibility of FEV<inf>1</inf> and Eosinophilic Airway Inflammation in COPD
2017, Archivos de BronconeumologiaCitation Excerpt :The fully adjusted OR was 4.262 (95% CI = 1.165–15.595, P=.029, Table 2). When subjects were dichotomized by FEV1 increment >15% from pre-dose values (ACCP criteria for positive bronchodilator reversibility),15 a subtle albeit statistically significant difference in the levels of sputum eosinophils was observed (1.78 vs 1.00%, P=.04, Table A2 in the appendix). ROC analysis showed an area under the curve of 0.58, P=.034 (Fig. 2).
Radiological correlates and clinical implications of the paradoxical lung function response to β<inf>2</inf> agonists: An observational study
2014, The Lancet Respiratory MedicineCitation Excerpt :Generally, a change of 100 mL in FEV1 is clinically significant because it can often be perceived by patients.19 Since these cutoffs remain arbitrary, we also defined paradoxical response with 10% and 15% thresholds for change in FEV120 and noted they were similar predictors of paradoxical response. The mechanisms underlying a paradoxical response remain unknown.
Assay of IL-22 and IL-25 in serum, whole blood, and peripheral blood mononuclear cell cultures of patients with severe asthma
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