Abstract
Serotonin is known to play a role in brain development prior to the time it assumes its role as a neurotransmitter in the mature brain. Serotonin regulates both the development of serotonergic neurons (termed autoregulation of development) and the development of target tissues. In both cases, the astroglial-derived protein, S-100beta plays a role. Disruption of serotonergic development can leave permanent alterations in brain function and behavior. This may be the case in such human developmental illnesses as autism and Down Syndrome.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Autistic Disorder / genetics
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Autistic Disorder / metabolism
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Brain / abnormalities*
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Brain / growth & development
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Brain / metabolism*
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Cell Differentiation / genetics*
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Down Syndrome / genetics
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Down Syndrome / metabolism
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Humans
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Nerve Growth Factors
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Neurons / metabolism*
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Neurons / pathology
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S100 Calcium Binding Protein beta Subunit
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S100 Proteins / genetics*
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Serotonin / metabolism*
Substances
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Nerve Growth Factors
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S100 Calcium Binding Protein beta Subunit
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S100 Proteins
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Serotonin