Regulation of cullin-based ubiquitin ligases by the Nedd8/RUB ubiquitin-like proteins

Geraint Parry; Mark Estelle

doi:10.1016/j.semcdb.2003.12.003

Regulation of cullin-based ubiquitin ligases by the Nedd8/RUB ubiquitin-like proteins

Semin Cell Dev Biol. 2004 Apr;15(2):221-9. doi: 10.1016/j.semcdb.2003.12.003.

Authors

Geraint Parry¹, Mark Estelle

Affiliation

¹ Department of Biology, Indiana University, Myers Hall 150, 915 East Third Street, Bloomington, IN 47405, USA.

PMID: 15209382
DOI: 10.1016/j.semcdb.2003.12.003

Abstract

The expression of the ubiquitin related protein Nedd8/RUB is essential for growth in most organisms. Nedd8/RUB has been shown to modify the cullin subunit of culling-based ubiquitin protein ligases (E3). Neddylation acts to regulate the function of these E3s and organisms with lesions in the neddylation process exhibit severe growth defects. In this review we describe the proteins that participate in neddylation and discuss a model for Nedd8/RUB regulation of ubiquitin ligase function.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Cullin Proteins / metabolism*
Humans
NEDD8 Protein
Protein Processing, Post-Translational*
Ubiquitins / chemistry
Ubiquitins / metabolism*

Substances

Cullin Proteins
NEDD8 Protein
NEDD8 protein, human
Ubiquitins

Grants and funding

GM43644/GM/NIGMS NIH HHS/United States