Abstract
We have encountered five hemodialysis patients who had received enteral nutrition and recovered from erythropoietin-resistant anemia with neutropenia after the correction of copper deficiency. We reduced the required doses of recombinant human erythropoietin (rHuEPO) to maintain the target hematocrit levels and three patients were finally weaned from the rHuEPO therapy. Thus, copper deficiency is involved in erythropoietin-resistant anemia in hemodialysis patients.
MeSH terms
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Anemia / drug therapy*
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Ceruloplasmin / analysis
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Copper / blood
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Copper / deficiency*
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Copper Sulfate / administration & dosage
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Copper Sulfate / therapeutic use
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Deficiency Diseases / etiology
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Deficiency Diseases / therapy
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Enteral Nutrition / adverse effects*
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Erythropoietin / administration & dosage
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Erythropoietin / therapeutic use*
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Female
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Humans
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Kidney Failure, Chronic / complications*
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Kidney Failure, Chronic / therapy
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Middle Aged
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Neutropenia / etiology
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Recombinant Proteins
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Renal Dialysis
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Treatment Failure
Substances
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Recombinant Proteins
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Erythropoietin
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Copper
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Ceruloplasmin
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Copper Sulfate