Abstract
Part I of this article, which appeared in the previous issue of the Journal, reviewed calcineurin inhibitors--ciclosporin and tacrolimus. In part II, we review the pharmacokinetics and therapeutic drug monitoring of mycophenolate and mammalian target of rapamycin inhibitors--sirolimus and everolimus--in thoracic transplantation, and we provide an overall discussion and suggest various areas for future study.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Heart Transplantation / methods*
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Heart Transplantation / physiology
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Heart Transplantation / trends
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Humans
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Immunosuppression Therapy / methods*
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Immunosuppression Therapy / trends
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Immunosuppressive Agents / pharmacokinetics*
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Immunosuppressive Agents / therapeutic use*
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Lung Transplantation / methods*
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Lung Transplantation / physiology
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Lung Transplantation / trends
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Thoracic Surgical Procedures / methods
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Thoracic Surgical Procedures / trends
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Tissue Distribution / drug effects
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Tissue Distribution / physiology