Epidemiological studies demonstrate an increased risk of colorectal cancer in patients with inflammatory bowel disease (IBD). A detailed literature review was conducted on epidemiology, risk factors, pathophysiology, chemoprevention and outcomes of colorectal cancer (CRC) in IBD as part of the 3rd ECCO scientific pathogenesis workshop.
Keywords: 5-ASA; 5-amino salicylic acid; AOM; Azoxymethane; CAC; CD; CIN; CRC; Chemoprevention; Chromosomal instability; Colitis-associated cancer; Colorectal cancer; Crohn's disease; DSS; Dextran sodium sulphate; Epidemiology; IBD; IC; IL; Indeterminate colitis; Inflammatory bowel disease; Interleukins; MRR; MSI; Microsatellite instability; Mortality rate ratio; NF-κB; Nuclear factor-κB; OR; Odds ratio; Outcomes; PSC; Pathogenesis; Primary sclerosing cholangitis; RR; Relative risk; SIR; Standardised incidence ratio; TGFβ; TLR; TNFα; Toll-like receptor; Transforming growth factor-β; Tumour necrosis factor-α; UC; Ulcerative colitis.
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