Leukocyte chemotactic factor 2 (LECT2) amyloidosis presenting as pulmonary-renal syndrome: a case report and review of the literature

Mazdak A Khalighi; Andrew Yue; Mei-Tsuey Hwang; William D Wallace

doi:10.1093/ckj/sft126

Leukocyte chemotactic factor 2 (LECT2) amyloidosis presenting as pulmonary-renal syndrome: a case report and review of the literature

Clin Kidney J. 2013 Dec;6(6):618-21. doi: 10.1093/ckj/sft126.

Authors

Mazdak A Khalighi¹, Andrew Yue², Mei-Tsuey Hwang³, William D Wallace⁴

Affiliations

¹ Department of Pathology , University of Chicago , Chicago, IL , USA.
² Department of Internal Medicine , University of California , San Francisco, Fresno, CA , USA.
³ Department of Nephrology , University of California , San Francisco, Fresno, CA , USA.
⁴ Department of Pathology and Laboratory Medicine , University of California , Los Angeles, CA , USA.

Abstract

Leukocyte chemotactic factor-2 (LECT2) amyloidosis has been described as being associated with kidney disease; however, no clinical manifestations outside of the kidney have been previously reported. We describe a patient presenting with pulmonary-renal syndrome found to have deposition of amyloidogenic LECT2 (ALECT2) within both the lung and the kidney. This case is unique in regard to both the patient's clinical presentation of pulmonary-renal syndrome in the setting of amyloidosis and the biopsy finding of ALECT2 deposition within the lung. It also emphasizes the importance of tissue diagnosis in such cases, given that amyloidosis was not initially considered in the differential diagnosis.

Keywords: amyloid; lect2; pulmonary-renal syndrome.