Compared to normal controls, individuals with Crohn's Disease manifest an increased prevalence of anxiety, depression and panic disorder occurring at any time in their life. Only panic disorder had an excess prevalence in Crohn's disease relative to community dwelling normals prior to the time of disease onset. Individuals with ulcerative colitis did not demonstrate an increased prevalence of psychiatric disorder before or after disease onset. The results suggest that there is a higher prevalence of psychiatric disorder in patients with Crohn's Disease relative to the normal population and that a small but significant percentage of individuals with Crohn's Disease may have a psychiatric disturbance which predates their medical illness.