Two receptors for leukotriene B 4 (LTB 4 ) have been molecularly identified: BLT1 and BLT2.
Both receptors are G protein-coupled seven transmembrane domain receptors, whose …

Idiopathic pulmonary fibrosis (IPF) is characterized by the progressive and ultimately fatal
accumulation of fibroblasts and extracellular matrix in the lung that distorts its architecture and …

Idiopathic pulmonary fibrosis (IPF) is a devastating disease, with a median survival as short
as 3 years from the time of diagnosis and no pharmacological therapies yet approved by the …

Aberrant wound-healing responses to injury have been implicated in the development of
pulmonary fibrosis, but the mediators directing these pathologic responses have yet to be fully …

Tissue stiffening is a hallmark of fibrotic disorders but has traditionally been regarded as an
outcome of fibrosis, not a contributing factor to pathogenesis. In this study, we show that …

… off-target mutations via target capture sequencing in HSPCs and observed low levels of
off-target … ablate genes in HSPCs with minimal off-target mutagenesis, which could have broad …

Allergic and parasitic worm immunity is characterized by infiltration of tissues with interleukin
(IL)-4- and IL-13-expressing cells, including T-helper-2 cells, eosinophils and basophils 1 . …

Pathological fibrosis is driven by a feedback loop in which the fibrotic extracellular matrix is
both a cause and consequence of fibroblast activation. However, the molecular mechanisms …

Leukotriene B 4 (LTB 4 ) was originally described as a potent lipid myeloid cell chemoattractant,
rapidly generated from innate immune cells, that activates leukocytes through the G …

Leukotriene B 4 (LTB 4 ) is a potent chemoattractant for myeloid leukocytes, which express
BLT1, the high-affinity receptor for LTB 4 . We report here that BLT1 is induced substantially …