Disturbances in endothelial cell (EC) barrier regulation are critically dependent upon
rearrangements of EC actin cytoskeleton. However, the role of microtubule (MT) network in the …

Ventilator-induced lung injury syndromes are characterized by profound increases in vascular
leakiness and activation of inflammatory processes. To explore whether excessive cyclic …

Thrombin-induced barrier dysfunction of pulmonary endothelial monolayer is associated
with dramatic cytoskeletal reorganization, activation of actomyosin contraction, and gap …

Prostaglandin E 2 (PGE 2 ) and prostacyclin are lipid mediators produced by cyclooxygenase
and implicated in the regulation of vascular function, wound repair, inflammatory processes…

Hemodynamic forces in the form of shear stress (SS) and mechanical strain imposed by
circulating blood are recognized factors involved in the control of systemic endothelial cell (EC) …

Barrier dysfunction of pulmonary endothelial monolayer is associated with dramatic cytoskeletal
reorganization, activation of actomyosin contractility, and gap formation. The linkage …

… with plasmids encoding either the GEF-H1 (AA 1–894), GEF-H1 (AA 1–572), or GEF-H1(DH) …
The authors thank Nurgul Moldobaeva for superb laboratory assistance and Maria Birukova …

Alterations of cell monolayer integrity and increased vascular permeability are key to many
pathologies, including atherosclerosis, stroke, lung injury, cancer, digestive disorders and …

The maintenance of endothelial barrier integrity is absolutely essential to prevent the vascular
leak associated with pneumonia, pulmonary edema resulting from inhalation of toxins, …

Oxidative stress is an important part of host innate immune response to foreign pathogens,
such as bacterial LPS, but excessive activation of redox signaling may lead to pathologic …