Alzheimer's disease: many failed trials, so where do we go from here?

AB Reiss, AD Glass, T Wisniewski… - Journal of …, 2020 - journals.sagepub.com
Alzheimer's disease (AD) is a neurodegenerative brain disorder associated with relentlessly
progressive cognitive impairment and memory loss. AD pathology proceeds for decades …

Methotrexate effects on adenosine receptor expression in peripheral monocytes of persons with type 2 diabetes and cardiovascular disease

AB Reiss, I Teboul, L Kasselman… - Journal of …, 2022 - journals.sagepub.com
The Cardiovascular Inflammation Reduction Trial (CIRT) was designed to assess whether
low-dose methotrexate (LD-MTX) would reduce future cardiac events in patients with …

Regulation of cerebral cholesterol metabolism in Alzheimer disease

AB Reiss, I Voloshyna - Journal of Investigative Medicine, 2012 - journals.sagepub.com
Alzheimer disease (AD) is an age-related neurodegenerative disorder that manifests as a
progressive loss of memory and deterioration of higher cognitive functions. Alzheimer disease …

Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces Alzheimer disease-associated tau hyperphosphorylation in the hippocampus of rats with type 2 …

W Xu, Y Yang, G Yuan, W Zhu… - Journal of investigative …, 2015 - journals.sagepub.com
Background Impaired insulin signaling pathway in the brain in type 2 diabetes (T2D) is a risk
factor for Alzheimer disease (AD). Glucagon-like peptide-1 (GLP-1) and its receptor agonist …

Proteomics in stroke research: potentials of the nascent proteomics

A Zhou - Journal of Investigative Medicine, 2016 - journals.sagepub.com
Among omics, the proteomics assumes a unique role in that it offers the effectors or actuators
of a biological condition. This brief review attempts to summarize the development in a …

What does fluorodeoxyglucose PET imaging add to a clinical diagnosis of dementia?

W Jagust, B Reed, D Mungas, W Ellis, C Decarli - Neurology, 2007 - AAN Enterprises
Background: Few studies have compared the accuracy of [ 18 F]fluorodeoxyglucose (FDG)
PET to the accuracy of clinical and pathologic diagnosis in dementia patients. Methods: Forty-…

Protective effects of a natural product, curcumin, against amyloid β induced mitochondrial and synaptic toxicities in Alzheimer's disease

PH Reddy, M Manczak, X Yin… - Journal of …, 2016 - journals.sagepub.com
The purpose of our study was to investigate the protective effects of a natural product—‘curcumin’—
in Alzheimer's disease (AD)-like neurons. Although much research has been done …

CNS findings in chronic fatigue syndrome and a neuropathological case report

K Ferrero, M Silver, A Cocchetto… - Journal of …, 2017 - journals.sagepub.com
Chronic fatigue syndrome (CFS) is characterized as a persistent, debilitating complex disorder
of unknown etiology, whereby patients suffer from extreme fatigue, which often presents …

NAWL Welcomes New Members

A Newman - HeinOnline
Membership in the National Association of Women Lawyers has many advantages, among
them, opportunities for continuing legal education, a subscription to the Women Lawyers …

Imaging markers for Alzheimer disease: which vs how

GB Frisoni, M Bocchetta, G Chételat, GD Rabinovici… - Neurology, 2013 - AAN Enterprises
Revised diagnostic criteria for Alzheimer disease (AD) acknowledge a key role of imaging
biomarkers for early diagnosis. Diagnostic accuracy depends on which marker (ie, amyloid …