Haptoglobin is primarily produced in the liver and is functionally important for binding free
hemoglobin from lysed red cells in vivo, preventing its toxic effects. Because haptoglobin …

Here we investigated different cell populations within ovarian cancer using single-cell RNA
seq: fourteen samples from nine patients with differing grades (high grade, low grade and …

Extracellular cold-inducible RNA-binding protein (eCIRP) is a key mediator of severity and
mortality in sepsis. We found that stimulation of mouse bone marrow–derived neutrophils (…

Background Endometriosis is a common, complex disorder which is underrecognized and
subject to prolonged delays in diagnosis. It is accompanied by significant changes in the …

Background Endometriosis is a chronic and underdiagnosed disease which affects 5–10%
of women of childbearing age and is characterized by growth of endometrial tissue outside of …

BACKGROUND The use of massive transfusion protocols (MTPs) in the resuscitation of
hemorrhaging trauma patients ensures rapid delivery of blood products to improve outcomes, …

Background ABO blood groups have been linked to susceptibility to infection with certain
microorganisms, including coronaviruses. We examined the relationship between blood group …

Objective B lymphoid kinase (BLK) is associated with rheumatoid arthritis (RA) and several
other B cell–associated autoimmune disorders. BLK risk variants are consistently associated …

Intravenous bisphosphonates can cause acute kidney injury; however, this risk was not found
with oral bisphosphonates in randomized clinical trials with restrictive eligibility criteria. In …

Direct oral anticoagulants (DOACs) have at least noninferior efficacy compared with other
oral anticoagulants and have ancillary benefits, including overall better safety profiles, lack of …