The therapeutic options for ameliorating the profound vascular permeability, alveolar
flooding, and organ dysfunction that accompanies acute inflammatory lung injury (ALI) remain …

… 6C) in the TLR4-binding region on MD-2 was well aligned in the N-to-C order with a loop
residing in NAMPT/PBEF in the reverse C-to-N order (457L-445E, red, Fig. 6D, 30.3% identity). …

… (B, C) We next used PBEF neutralizing antibody (88 μg) via intratracheal delivery in VILIb-challenged
B6 mice and determined that PBEF Ab reduces (B) VILI-induced PMN …

Acute lung injury (ALI) and mechanical ventilator-induced lung injury (VILI), major causes of
acute respiratory failure with elevated morbidity and mortality, are characterized by …

We explored the mechanistic involvement of the growth arrest and DNA damage-inducible
gene GADD45a in lipopolysaccharide (LPS)-and ventilator-induced inflammatory lung injury (…

Clinically significant radiation-induced lung injury (RILI) is a common toxicity in patients
administered thoracic radiotherapy. Although the molecular etiology is poorly understood, we …

Microvascular injury and increased vascular leakage are prominent features of radiation-induced
lung injury (RILI), and often follow cancer-associated thoracic irradiation. Our previous …

We have generated genetically engineered mice that are uniquely susceptible to
lipopolysaccharide (LPS)-induced and mechanical ventilation–induced lung injury in a sex-specific …

Coronary heart disease, specifically, myocardial infarction, is the number one killer in
women. Women need to be educated about this disease and assisted in making behavioral …

In an effort to provide additional insight on providing a secure teaching and learning
environment within schools, this study sought to: 1) explore the safety and health practices within …