Sustained release of endothelial progenitor cell-derived extracellular vesicles from shear-thinning hydrogels improves angiogenesis and promotes function after …
… Carol W Chen , Carol W Chen … Briefly, hydrogels at 4% w/w were prepared from lyophilized
polymers of Ad-HA and CD-HA dissolved in PBS and mixed. The mechanical properties and …
polymers of Ad-HA and CD-HA dissolved in PBS and mixed. The mechanical properties and …
Low ejection fraction in donor hearts is not directly associated with increased recipient mortality
CW Chen, MH Sprys, AC Gaffey, JJ Chung… - The Journal of Heart and …, 2017 - Elsevier
Background Reduced left ventricular ejection fraction (EF) in the donor heart is often a
contraindication for transplant. However, small studies have validated the use of hearts with …
contraindication for transplant. However, small studies have validated the use of hearts with …
[HTML][HTML] Delayed delivery of endothelial progenitor cell-derived extracellular vesicles via shear thinning gel improves postinfarct hemodynamics
Background Extracellular vesicles (EVs) are promising therapeutics for cardiovascular
disease, but poorly-timed delivery might hinder efficacy. We characterized the time-dependent …
disease, but poorly-timed delivery might hinder efficacy. We characterized the time-dependent …
[HTML][HTML] Transplantation of “high-risk” donor hearts: implications for infection
…, AM Thomasson, C Venkataraman, CW Chen… - The Journal of thoracic …, 2016 - Elsevier
Background Heart transplantation is the gold-standard treatment for end-stage heart failure.
Short- and long-term outcomes have been excellent, but the shortage of organs persists. …
Short- and long-term outcomes have been excellent, but the shortage of organs persists. …
[HTML][HTML] Delivery of progenitor cells with injectable shear-thinning hydrogel maintains geometry and normalizes strain to stabilize cardiac function after ischemia
AC Gaffey, MH Chen, A Trubelja… - The Journal of thoracic …, 2019 - Elsevier
Objectives The ventricle undergoes adverse remodeling after myocardial infarction,
resulting in abnormal biomechanics and decreased function. We hypothesize that tissue-engineered …
resulting in abnormal biomechanics and decreased function. We hypothesize that tissue-engineered …
[HTML][HTML] Preoperative renal dysfunction does not affect outcomes of left ventricular assist device implantation
A Kilic, CW Chen, AC Gaffey, JW Wald… - The Journal of thoracic …, 2018 - Elsevier
Objective Selection criteria for durable left ventricular assist device (LVAD) implantation
remain unclear. One such criterion is renal function. In this study we evaluated outcomes of …
remain unclear. One such criterion is renal function. In this study we evaluated outcomes of …
[HTML][HTML] Is there a difference in bleeding after left ventricular assist device implant: centrifugal versus axial?
AC Gaffey, CW Chen, JJ Chung, J Han… - Journal of …, 2018 - Springer
Background Continuous-flow left ventricular assist devices (CF-LVAD) have become the
standard of care for patients with end stage heart failure. Device reliability has increased, …
standard of care for patients with end stage heart failure. Device reliability has increased, …
… course and complications in interagency registry for mechanically assisted circulatory support 1 (INTERMACS) patients managed with or without extracorporeal …
JJ Han, J Chung, CW Chen, AC Gaffey… - ASAIO …, 2018 - journals.lww.com
Extracorporeal membrane oxygenation (ECMO) as a bridge to left ventricular assist device (LVAD)
implantation has shown promise in improving end-organ function and optimizing …
implantation has shown promise in improving end-organ function and optimizing …
Therapeutic efficacy of cryopreserved, allogeneic extracellular vesicles for treatment of acute myocardial infarction
…, Z Tran, CW Chen, P Altshuler, M Chen… - International heart …, 2021 - jstage.jst.go.jp
Extracellular vesicles (EV) that are derived from endothelial progenitor cells (EPC) have
been determined to be a novel therapy for acute myocardial infarction, with a promise for …
been determined to be a novel therapy for acute myocardial infarction, with a promise for …
Higher body mass index increases risk of HeartMate II pump thrombosis but does not adversely affect long-term survival
JJ Han, R Sooppan, AP Johnson, CW Chen… - Circulation …, 2017 - jstage.jst.go.jp
Background: Obesity has been correlated with various adverse events in patients who receive
left ventricular assist devices (LVAD). In this study, we sought to further characterize the …
left ventricular assist devices (LVAD). In this study, we sought to further characterize the …