Study Objectives: Narcolepsy with cataplexy is caused by a loss of orexin (hypocretin)
signaling, but the physiologic mechanisms that result in poor maintenance of wakefulness and …

A workshop was held at the National Institute for Diabetes and Digestive and Kidney
Diseases with a focus on the impact of sleep and circadian disruption on energy balance and …

Light at night in adults suppresses melatonin in a nonlinear intensity‐dependent manner. In
children, bright light of a single intensity before bedtime has a robust melatonin suppressing …

Introduction The Oral Minimal Model (OMM), a differential-equations based mathematical
model of glucose-insulin dynamics, utilizes data from a frequently sampled oral glucose …

Context To our knowledge, circadian rhythms have not been examined in girls with polycystic
ovarian syndrome (PCOS), despite the typical delayed circadian timing of adolescence, …

Late sleep timing is prevalent in early childhood and a risk factor for poor behavioral and
health outcomes. Sleep timing is influenced by the phase of the circadian clock, with later …

This study presents a novel mathematical modeling framework that is uniquely suited to
investigating the structure and dynamics of the sleep-wake regulatory network in the brain stem …

Objectives To examine the relationship between insulin resistance (IR) and sleep/circadian
health in overweight/obese adolescents. We hypothesized that insufficient and delayed …

Study Objectives: Narcolepsy is caused by loss of the orexin (also known as hypocretin)
neurons. In addition to the orexin peptides, these neurons release additional neurotransmitters, …

Study Objectives We determine if young people with narcolepsy type 1 (NT1), narcolepsy
type 2 (NT2), and idiopathic hypersomnia (IH) have distinct nocturnal sleep stability …