Background The time to initiate intravenous thrombolysis for acute ischemic stroke is generally
limited to within 4.5 hours after the onset of symptoms. Some trials have suggested that …

Alzheimer disease (AD) accounts for 60–70% of dementia cases. Given the seriousness of
the disease and continual increase in patient numbers, developing effective therapies to treat …

Background: Diabetic neuropathy is a common complication in diabetes, with patients typically
experiencing diverse sensory symptoms including dysesthesias in the feet and usually …

Alzheimer's disease (AD) is the leading cause of dementia, presenting a significant unmet
medical need worldwide. The pathogenesis of AD involves various pathophysiological events, …

Epidemiological evidence reveals that patients with type 2 diabetes mellitus (T2DM) have an
increased risk of neurodegenerative diseases (NDs), including dementia and Parkinson's …

Amyloid-β (Aβ) is the core component of senile plaques, which are the pathological markers
for Alzheimer’s disease and cerebral amyloid angiopathy. DNA methylation/demethylation …

… Chaur-Jong Hu critically revised the manuscript for important intellectual content. Dr. Hung-Yi
Chiou has full access to all data in this study, has the right to publish any or all of the data, …

Background: Insulin resistance (IR), considered a hallmark of diabetes at the cellular level,
is implicated in pre-diabetes, results in type 2 diabetes, and negatively affects mitochondrial …

Background Dementia patients often present with coexisting medical conditions and potentially
face higher risk of complications during hospitalization. Because the general features of …

Objective To investigate the associated risk of epilepsy after traumatic brain injury (TBI) in a
population-based retrospective cohort study. Methods Using Taiwan's National Health …