Late-stage breast cancer metastasis is driven by dysregulated TGF-β signaling, but the
underlying molecular mechanisms have not been fully elucidated. We attempted to recapitulate …

BACKGROUND: Short duration and poor quality of sleep have been associated with increased
risks of obesity, cardiovascular disease, diabetes mellitus, and total mortality. However, …

PD-L1 expression in the tumor immune microenvironment is recognized as both a prognostic
and predictive biomarker in patients with cutaneous melanoma, a finding closely related to …

Circulating exosomes provide a promising approach to assess novel and dynamic biomarkers
in human disease, due to their stability, accessibility and representation of molecules from …

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is an enduring public health
problem globally, particularly in sub-Saharan Africa. Several studies have suggested a role …

Genome-wide platforms for high-throughput profiling of circulating miRNA (oligoarray or miR-Seq)
offer enormous promise for agnostic discovery of circulating miRNA biomarkers as a …

Purpose: MR‐based pseudo‐CT has an important role in MR‐based radiation therapy
planning and PET attenuation correction. The purpose of this study is to establish a clinically …

Formation of mutagenic heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs)
is one pathway believed to drive the association of colon cancer with meat …

Background It is postulated that high serum levels of insulin and insulin growth factor 1 (IGF-1)
mediate obesity-associated carcinogenesis. The relationship of insulin, IGF-1 and IGF …

The FERM domain containing protein Kindlin-3 has been recognized as a major regulator of
integrin function in hematopoietic cells, but its role in neoplasia is totally unknown. We have …