The Hsp70 family members play an essential role in cellular protein metabolism by acting
as polypeptide-binding and release factors that interact with nonnative regions of proteins at …

The pinacol rearrangement1 is a well-known reaction. It refers to the acid-catalyzed transformation
of 1, 2-diols to ketones or aldehydes by 1, 2-migration of a CÀC or CÀH bond toward …

High costs, long test times, and societal concerns related to animal use have required the
development of in vitro assays for the rapid and cost-effective toxicological evaluation and …

Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent, …

INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities.
Variations in human cortical surface area and thickness are associated with neurological, …

Importance Individuals with mental disorders often develop comorbidity over time. Past
studies of comorbidity have often restricted analyses to a subset of disorders and few studies …

Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology.
Understanding the genetic factors contributing to the shared and disorder-specific symptoms …

Cystic fibrosis arises from the misfolding and premature degradation of CFTRΔF508, a Cl −
ion channel with a single amino acid deletion. Yet, the quality-control machinery that selects …

The early genetic pathway(s) triggering the pathogenesis of coronary artery disease (CAD)
and myocardial infarction (MI) remain largely unknown. Here, we describe an autosomal …

Background Identifying individuals at risk for developing Alzheimer disease (AD) is of utmost
importance. Although genetic studies have identified AD-associated SNPs in APOE and …