Fibrosis is a process characterized by an excessive accumulation of the extracellular matrix
as a response to different types of tissue injuries, which leads to organ dysfunction. The …

The key players of the chronic kidney disease-mineral and bone disorders (CKD-MBD) are
calcium, phosphate, PTH, FGF23, and the vitamin D hormonal system. The progressive …

Bone loss and increased fractures are common complications in chronic kidney disease.
Because Wnt pathway activation is essential for normal bone mineralization, we assessed …

Fibrosis plays an important role in the pathogenesis of long-term diabetic complications and
contributes to the development of cardiac and renal dysfunction. The aim of this …

Background In chronic kidney disease (CKD), increases in serum phosphate and parathyroid
hormone (PTH) aggravate vascular calcification (VC) and bone loss. This study was …

Preclinical biomedical models are a fundamental tool to improve the knowledge and
management of diseases, particularly in diabetes mellitus (DM) since, currently, the …

Background In chronic kidney disease, the activation of the renin–angiotensin–aldosterone
system (RAAS) and renal inflammation stimulates renal fibrosis and the progression to end-…

This study was designed to investigate the controversy on the potential role of sKlotho as an
early biomarker in Chronic Kidney Disease–Mineral Bone Disorder (CKD-MBD), to assess …

BACKGROUND: Vascular calcification (VC) is a highly prevalent complication of chronic
kidney disease (CKD) and is associated with the higher morbidity-mortality of patients with CKD…

Background In chronic kidney disease, serum phosphorus (P) elevations stimulate parathyroid
hormone (PTH) production, causing severe alterations in the bone–vasculature axis. PTH …