Lipoprotein lipase (LPL), identified in the 1950s, has been studied intensively by biochemists,
physiologists, and clinical investigators. These efforts uncovered a central role for LPL in …

The mechanisms underlying sterol transport in mammalian cells are poorly understood. In
particular, how cholesterol internalized from HDL is made available to the cell for storage or …

Coenzyme Q biosynthesis in yeast requires a multi-subunit Coq polypeptide complex. Deletion
of any one of the COQ genes leads to respiratory deficiency and decreased levels of the …

Over the past few decades, several approaches have been used to image lipids in cells and
tissues, but most have limited spatial resolution and sensitivity. Here, we discuss a relatively …

Plasma membranes of animal cells are enriched for cholesterol. Cholesterol-dependent
cytolysins (CDCs) are pore-forming toxins secreted by bacteria that target membrane …

Cholesterol is a crucial lipid within the plasma membrane of mammalian cells. Recent
biochemical studies showed that one pool of cholesterol in the plasma membrane is “accessible” …

Background Steroidogenic acute regulatory protein (StAR)-related lipid transfer (START)
domains were first identified from mammalian proteins that bind lipid/sterol ligands via a …

The processing of triglyceride-rich lipoproteins (TRLs) in capillaries provides lipids for vital
tissues, but our understanding of TRL metabolism is limited, in part because TRL processing …

Recent studies have demonstrated the existence of a discrete pool of cholesterol in the
plasma membranes (PM) of mammalian cells—referred to as the accessible cholesterol pool—…

Nucleic acid therapeutics (NATs) have proven useful in promoting the degradation of specific
transcripts, modifying gene expression, and regulating mRNA splicing. In each situation, …