Cannabinoid research underwent a tremendous increase during the last 10 years. This
progress was made possible by the discovery of cannabinoid receptors and the endogenous …

Allergic diseases have in common a dysfunctional epithelial barrier, which allows the penetration
of allergens and microbes, leading to the release of type 2 cytokines that drive allergic …

Acute lung injury (ALI) attributable to sepsis or mechanical ventilation and subacute lung injury
because of ionizing radiation (RILI) share profound increases in vascular permeability as …

Alveolar cell apoptosis is involved in the pathogenesis of emphysema, a prevalent disease
primarily caused by cigarette smoking. We report that ceramide, a second messenger lipid, is …

Lipids in the stratum corneum of atopic dermatitis (AD) patients differ substantially in composition
from healthy subjects. We hypothesized that hyperactivated type 2 immune response …

The role of ceramide neo-genesis in cellular stress response signaling is gaining increasing
attention with recent progress in elucidating the novel roles and biochemical properties of …

Although alveolar macrophages (AMs) from patients with asthma are known to be functionally
different from those of healthy individuals, the mechanism by which this transformation …

Skin barrier dysfunction has been reported in both atopic dermatitis (AD) and food allergy (FA).
However, only one-third of patients with AD have FA. The purpose of this study was to …

The effects of arachidonic acid ethanolamide (anandamide), palmitoylethanolamide and Δ
9 -tetrahydrocannabinol on the production of tumor necrosis factor-α (TNF-α), interleukin-4, …

Novel immunomodulatory molecule FTY720 is a synthetic analog of myriocin, but unlike
myriocin FTY720 does not inhibit serine palmitoyltransferase. Although many of the effects of …