Fecal microbiota transplantation: in perspective

…, E Allen-Vercoe, EO Petrof - Therapeutic advances in …, 2016 - journals.sagepub.com
There has been increasing interest in understanding the role of the human gut microbiome
to elucidate the therapeutic potential of its manipulation. Fecal microbiota transplantation (…

From stool transplants to next-generation microbiota therapeutics

EO Petrof, A Khoruts - Gastroenterology, 2014 - Elsevier
… that were absent in patients with relapsing CDI (the 3 Bacteroides strains) and on data from
in vitro assays for bacteria that inhibit C difficile (R productus, C bifermentans, and 1 of the E

Microbial ecosystems therapeutics: a new paradigm in medicine?

EO Petrof, EC Claud, GB Gloor… - Beneficial …, 2013 - wageningenacademic.com
Increasing evidence indicates that the complex microbial ecosystem of the human intestine
plays a critical role in protecting the host against disease. This review discusses gut …

[HTML][HTML] Stool substitute transplant therapy for the eradication of Clostridium difficile infection: 'RePOOPulating' the gut

EO Petrof, GB Gloor, SJ Vanner, SJ Weese, D Carter… - Microbiome, 2013 - Springer
Background Fecal bacteriotherapy (‘stool transplant’) can be effective in treating recurrent
Clostridium difficile infection, but concerns of donor infection transmission and patient …

16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis

…, JD Hoenig, KJ Malin, S Qamar, EO Petrof… - The ISME …, 2009 - academic.oup.com
… (e) Comparison of antibiotic exposure time between control and NEC groups. In all
panels, asterisk indicates statistical significance at P<0.05. NEC, necrotizing enterocolitis. …

Frozen vs fresh fecal microbiota transplantation and clinical resolution of diarrhea in patients with recurrent Clostridium difficile infection: a randomized clinical trial

CH Lee, T Steiner, EO Petrof, M Smieja, D Roscoe… - Jama, 2016 - jamanetwork.com
… Dr Petrof reported holding a patent for synthetic stool formation. Dr Crowther reported receiving
grants from the Heart and Stroke Foundation of Ontario, Leo Pharma, and Bayer, as well …

Probiotics inhibit nuclear factor-κB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition

EO Petrof, K Kojima, MJ Ropeleski, MW Musch, Y Tao… - Gastroenterology, 2004 - Elsevier
… (50 ng/mL) 6 hours before harvest, and compared with untreated control cells (No Tx), cells
treated with TNF-α alone (TNF-α only), or cells pretreated with conditioned media from the E

Soluble factors from Lactobacillus GG activate MAPKs and induce cytoprotective heat shock proteins in intestinal epithelial cells

…, O Schneewind, EB Chang, EO Petrof - … of Physiology-Cell …, 2006 - journals.physiology.org
Conditioned media from the probiotic Lactobacillus GG (LGG-CM) induce heat shock protein
(Hsp) expression in intestinal epithelial cells. LGG-CM induces both Hsp25 and Hsp72 in a …

Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis

S Wu, Y Zhang, R Lu, Y Xia, D Zhou, EO Petrof… - Gut, 2015 - gut.bmj.com
… (E) Bacterial community of faecal samples from VDR ΔIEC and VDR loxP/loxP mice
using 454 16S rRNA sequencing data (n=4/group). (F) Representative fluorescence in situ …

Salmonella effector AvrA regulation of colonic epithelial cell inflammation by deubiquitination

Z Ye, EO Petrof, D Boone, EC Claud, J Sun - The American journal of …, 2007 - Elsevier
… A recent study in enteropathogenic E. coli indicated that enteropathogenic E. coli-induced
inflammation involves a balance between pro- and anti-inflammatory proteins. Extracellular …