Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous
studies; however, a large portion of the genetic risk for this disease remains unexplained. …

We sought to identify new susceptibility loci for Alzheimer's disease through a staged
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease …

Individuals who are at risk for autosomal dominant polycystic kidney disease are often screened
by ultrasound using diagnostic criteria derived from individuals with mutations in PKD1. …

Apolipoprotein E (APOE) dependent lifetime risks (LTRs) for Alzheimer Disease (AD) are
currently not accurately known and odds ratios alone are insufficient to assess these risks. We …

… N Bogdanova did the genetic analysis of the Bulgarian families, Eliecer Coto and S Sanz
de Castro did the genetic and clinical analysis of the families in northern Spain, and S Jeffery …

Introducción y objetivos Las mutaciones en los genes sarcoméricos son la causa más frecuente
de miocardiopatía hipertrófica. Para cada gen, la frecuencia de mutaciones varía entre …

The D allele at the angiotensin-I-converting enzyme (ACE)-insertion/deletion polymorphism
has been associated with an increased risk of developing several pathological processes, …

The Angiotensin system is implicated in the pathogenesis of COVID-19. First, ACE2 is the
cellular receptor for SARS-CoV-2, and expression of the ACE2 gene could regulate the …

Mutations in different genes encoding sarcomeric proteins are responsible for 50–60% of
familial cases of hypertrophic cardiomyopathy (HCM); however, the genetic alterations causing …

Background There is increasing evidence of the key role that the gut microbiota plays in
inflammatory diseases. Objectives To identify differences in the faecal microbial composition of …