Perturbations in endoplasmic reticulum (ER) homeostasis can evoke stress responses
leading to aberrant glucose and lipid metabolism. ER dysfunction is linked to inflammatory …

Immune-mediated destruction of insulin-producing β cells causes type 1 diabetes (T1D).
However, how β cells participate in their own destruction during the disease process is poorly …

Notch signaling is a key mechanism in the control of embryogenesis. However, its in vivo
function during mesenchymal cell differentiation, and, specifically, in bone homeostasis, …

Mesenchymal stem cell-derived osteochondroprogenitors express two master transcription
factors, SOX9 and RUNX2, during condensation of the skeletal anlagen. They are essential …

Aims/hypothesis Proinflammatory cytokines contribute to beta cell damage in type 1 diabetes
in part through activation of endoplasmic reticulum (ER) stress. In rat beta cells, cytokine-…

Notch signaling plays an important role in developmental processes and adult tissue homeostasis.
Altered Notch signaling has been associated with various diseases including cancer. …

The liberation of energy stores from adipocytes is critical to support survival in times of energy
deficit; however, uncontrolled or chronic lipolysis associated with insulin resistance and/or …

The endoplasmic reticulum adapts to fluctuations in demand and copes with stress through
an adaptive signaling cascade called the unfolded protein response (UPR). Accumulating …

During the progression of type 1 diabetes (T1D), β cells are exposed to significant stress and,
therefore, require adaptive responses to survive. The adaptive mechanisms that can …

Evolutionarily conserved Notch signaling plays a critical role during embryonic and postnatal
life. The importance of Notch signaling in the determination of cell fate, and the spatio-…