Familial defective apolipoprotein (apo) B-100 is a genetic disease that leads to
hypercholesterolemia and to an increased serum concentration of low density lipoproteins that bind …

Context The risk of type 2 diabetes mellitus is heterogeneous among obese individuals.
Factors that discriminate prediabetes or diabetes risk within this population have not been well …

Previous in vivo turnover studies suggested that retarded clearance of low density lipoproteins
(LDL) from the plasma of some hypercholesterolemic patients is due to LDL with defective …

Selected missense mutations in the proprotein convertase subtilisin/kexin type 9 serine
protease gene (PCSK9) cause autosomal dominant hypercholesterolemia, whereas nonsense …

Familial defective apolipoprotein B-100 is a genetic disorder of apolipoprotein B-100 that
causes moderate to severe hypercholesterolemia. A single amino acid mutation in …

Background— The association between higher body mass index (BMI) and lower B-type
natriuretic peptide (BNP) level is thought to be mediated by expression of the natriuretic peptide …

Objective: Visceral (VAT) and abdominal subcutaneous (SAT) adipose tissues contribute to
obesity but may have different metabolic and atherosclerosis risk profiles. We sought to …

An approach to understand quantitative traits was recently proposed based on the finding
that nonsynonymous (NS) sequence variants in certain genes are preferentially enriched at …

Aldosterone promotes glomerular and tubular sclerosis independent of angiotensin II in animal
models of diabetic nephropathy. Most human studies testing the renoprotective benefit of …

Patients with combined hyperlipidemia (elevated triglyceride [TG] levels, elevated low-density
lipoprotein [LDL] cholesterol, and multiple lipoprotein abnormalities) are at increased risk …