Neuroinflammation in Alzheimer's disease
…, CA Dinarello, JC Breitner, GM Cole… - The Lancet …, 2015 - thelancet.com
Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the
neuronal compartment, but includes strong interactions with immunological mechanisms in …
neuronal compartment, but includes strong interactions with immunological mechanisms in …
Inflammation and Alzheimer's disease
Inflammation clearly occurs in pathologically vulnerable regions of the Alzheimer’s disease (AD)
brain, and it does so with the full complexity of local peripheral inflammatory responses. …
brain, and it does so with the full complexity of local peripheral inflammatory responses. …
The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
Inflammation in Alzheimer's disease (AD) patients is characterized by increased cytokines
and activated microglia. Epidemiological studies suggest reduced AD risk associates with long…
and activated microglia. Epidemiological studies suggest reduced AD risk associates with long…
Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease
…, KH Ashe, SA Frautschy, GM Cole - Journal of …, 2000 - Soc Neuroscience
The brain in Alzheimer's disease (AD) shows a chronic inflammatory response characterized
by activated glial cells and increased expression of cytokines and complement factors …
by activated glial cells and increased expression of cytokines and complement factors …
A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model
…, N Salem, SA Frautschy, GM Cole - Journal of …, 2005 - Soc Neuroscience
Epidemiological studies suggest that increased intake of the omega-3 (n-3) polyunsaturated
fatty acid (PUFA) docosahexaenoic acid (DHA) is associated with reduced risk of …
fatty acid (PUFA) docosahexaenoic acid (DHA) is associated with reduced risk of …
[HTML][HTML] Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model
Learning and memory depend on dendritic spine actin assembly and docosahexaenoic
acid (DHA), an essential n-3 (omega-3) polyunsaturated fatty acid (PFA). High DHA …
acid (DHA), an essential n-3 (omega-3) polyunsaturated fatty acid (PFA). High DHA …
[HTML][HTML] PET of brain amyloid and tau in mild cognitive impairment
…, H Lavretsky, AC Burggren, GM Cole… - … England Journal of …, 2006 - Mass Medical Soc
Background Amyloid senile plaques and tau neurofibrillary tangles are neuropathological
hallmarks of Alzheimer's disease that accumulate in the cortical regions of the brain in persons …
hallmarks of Alzheimer's disease that accumulate in the cortical regions of the brain in persons …
Microglial response to amyloid plaques in APPsw transgenic mice.
Microglial activation is central to the inflammatory response in Alzheimer's Disease (AD). A
recently described mouse line, Tg (HuAPP695. K670N/M671L) 2576, expressing human …
recently described mouse line, Tg (HuAPP695. K670N/M671L) 2576, expressing human …
Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease
…, B Hudspeth, S Hu, KF Faull, B Teter, GM Cole… - … of Pharmacology and …, 2008 - ASPET
Curcumin can reduce inflammation and neurodegeneration, but its chemical instability and
metabolism raise concerns, including whether the more stable metabolite tetrahydrocurcumin …
metabolism raise concerns, including whether the more stable metabolite tetrahydrocurcumin …
Vitamin E protects nerve cells from amyloid βprotein toxicity
The amyloid βprotein (ABP) is a 40 to 42 amino acid peptide which accumulates in Alzheimer's
disease plaques. It has been demonstrated that this peptide and a fragment derived from …
disease plaques. It has been demonstrated that this peptide and a fragment derived from …