In recent years, the focus of interest on the role of the renin-angiotensin system (RAS) in the
pathophysiology of hypertension and organ injury has changed to a major emphasis on the …

Intrarenal angiotensin II (Ang II) is regulated by several complex processes involving formation
from both systemically delivered and intrarenally formed substrate, as well as receptor-…

… Author links open overlay panel Hiroyuki Kobori , Lisa M. Harrison-Bernard , L. Gabriel
Navar … Kobori, LM Harrison-Bernard, LG Navar … Kobori, LM Harrison-Bernard, LG Navar …

This study was performed to examine whether there is an inappropriate regulation of
intrarenal angiotensinogen in Dahl-salt sensitive rats (DS) fed a high salt diet (HS). Dahl salt-…

Angiotensin II content in the kidney is much higher than in the plasma, and it increases
more in kidney diseases through an uncertain mechanism. Because the kidney abundantly …

Angiotensin II (AngII) infusions augment renal angiotensinogen mRNA and protein and urinary
angiotensinogen excretion (U AGT ). Further experiments were performed in 4 groups of …

The complexity of the intrarenal renin-angiotensin (Ang) system (RAS) continues to reveal
itself as evidence accumulates demonstrating its robust independent regulation in the …

Chronic elevations in circulating angiotensin II (AngII) levels produce sustained hypertension
and increased intrarenal AngII contents through multiple mechanisms, which may include …

Distal nephron renin may provide a possible pathway for angiotensin (Ang) I generation from
proximally delivered angiotensinogen. To examine the effects of Ang II on distal nephron …

We reported previously that urinary angiotensinogen (UAGT) levels provide a specific index
of the intrarenal renin-angiotensin system (RAS) status in angiotensin II–dependent …