Age-dependent changes in insulin action and body fat distribution are risk factors for the
development of type 2 diabetes. To examine whether the accumulation of visceral fat (VF) could …

One of the most robust observations in the biology of aging is that caloric restriction (CR)
extends life in a variety of species. Although CR results in substantial decrease in fat mass, the …

Aging is a natural process that involves a general decline in many physiological functions,
resulting in loss of function and eventually death. Extensive research is being performed in …

Context: The distribution of serum TSH shifts progressively to higher concentrations with age.
Objective: The aim of the study was to determine whether the population shift in TSH …

Background. Families of centenarians have high levels of plasma high-density lipoprotein (HDL)
cholesterol, which may have neurological as well as cardiovascular protective effects …

Increased fat mass, abdominal adiposity, and insulin resistance are typical findings in aging
mammals and are frequently associated with leptin resistance and increased plasma leptin …

Context: Exceptional longevity is associated with raised serum TSH. Objective: The aim of
this study was to examine whether offspring of people with exceptional longevity have …

Hypoglycemic episodes in patients with diabetes often go unrecognized, and over time,
patients may lose the ability to sense hypoglycemia, increasing their risk. Intensive diabetes …

OBJECTIVES: It is well recognized that a favorable lipid profile provides protection from
atherosclerotic cardiovascular disease. Because the major cause of nontraumatic death in the …

The demonstration of leptin receptors on the pancreatic β-cells suggests the possibility of direct
actions of leptin on insulin secretion. In vitro studies on islets or perfused pancreas and β-…