Although doxorubicin (DOX) is an effective anti-cancer drug with cytotoxicity in a variety of
different tumors, its effectiveness in treating glioblastoma multiforme (GBM) is constrained by …

Doxorubicin (DOX) is widely used for treating human cancers, but can induce heart failure
through an undefined mechanism. Herein we describe a previously unidentified signaling …

Temozolomide (TMZ) is a chemotherapy agent used to treat Grade IV astrocytoma, also
known as glioblastoma (GBM). TMZ treatment causes DNA damage that results in tumor cell …

Background Aminosilane-coated iron oxide nanoparticles (AmS-IONPs) have been widely
used in constructing complex and multifunctional drug delivery systems. However, the …

Lipotoxicity is a form of cellular stress caused by the accumulation of lipids resulting in
mitochondrial dysfunction and insulin resistance in muscle. Previously, we demonstrated that the …

Lung cancer is considered one of the most frequent causes of cancer-related death worldwide
and Non-Small Cell Lung Cancer (NSCLC) accounts for 80% of all lung cancer cases. …

Cardiac function is highly reliant on mitochondrial oxidative metabolism and quality control.
The circadian Clock gene is critically linked to vital physiological processes including …

OBJECTIVE: Although the combination of doxorubicin (Dox) and trastuzumab (Trz) reduces
breast cancer progression and recurrence, it is limited by significant cardiotoxic side effects. …

Oligodendroglial cell death and demyelination are hallmarks of neurotrauma and multiple
sclerosis that cause axonal damage and functional impairments. Remyelination remains a …

Hyaluronidases are endoglycosidases that initiate the breakdown of hyaluronan (HA), an
abundant component of the vertebrate extracellular matrix. In humans, six paralogous genes …