User profiles for Javad Alizadeh

Javad Alizadeh

Department of Human Anatomy and Cell Science, College of Medicine, University of …
Verified email at myumanitoba.ca
Cited by 15022

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

…, M Ali, MA Alim Al-Bari, S Aliwaini, J Alizadeh… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered the …

A novel electrochemical epinine sensor using amplified CuO nanoparticles and an-hexyl-3-methylimidazolium hexafluorophosphate electrode

…, I Sheikhshoaie, M Ranjbar, J Alizadeh… - New Journal of …, 2019 - pubs.rsc.org
This study suggests a carbon paste electrode modified with CuO nanoparticles and n-hexyl-3-methylimidazolium
hexafluorophosphate (CPE/CuO-NPs/HMIPF6) as a powerful tool for …

[HTML][HTML] Cellular commitment in the developing cerebellum

H Marzban, MR Del Bigio, J Alizadeh… - Frontiers in cellular …, 2015 - frontiersin.org
The mammalian cerebellum is located in the posterior cranial fossa and is critical for motor
coordination and non-motor functions including cognitive and emotional processes. The …

The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections

P Mehrbod, SR Ande, J Alizadeh, S Rahimizadeh… - Virulence, 2019 - Taylor & Francis
Virus infection induces different cellular responses in infected cells. These include cellular
stress responses like autophagy and unfolded protein response (UPR). Both autophagy and …

[HTML][HTML] Pleiotropic effects of statins: A focus on cancer

…, S Pecic, F Machaj, J Rosik, MJ Łos, J Alizadeh… - … et Biophysica Acta (BBA …, 2020 - Elsevier
The statin drugs (‘statins’) potently inhibit hydroxymethylglutaryl-coenzyme A (HMG-CoA)
reductase by competitively blocking the active site of the enzyme. Statins decrease de novo …

New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets

…, QM Chen, A Hudecki, A Sargazi, J Alizadeh… - Autophagy, 2017 - Taylor & Francis
Colorectal cancer (CRC), despite numerous therapeutic and screening attempts, still remains
a major life-threatening malignancy. CRC etiology entails both genetic and environmental …

Autophagy and the unfolded protein response promote profibrotic effects of TGF-β1 in human lung fibroblasts

…, A Samali, J Patterson, J Alizadeh… - … of Physiology-Lung …, 2018 - journals.physiology.org
Idiopathic pulmonary fibrosis (IPF) is a lethal fibrotic lung disease in adults with limited treatment
options. Autophagy and the unfolded protein response (UPR), fundamental processes …

[HTML][HTML] Mevalonate cascade inhibition by simvastatin induces the intrinsic apoptosis pathway via depletion of isoprenoids in tumor cells

J Alizadeh, AA Zeki, N Mirzaei, S Tewary… - Scientific reports, 2017 - nature.com
The mevalonate (MEV) cascade is responsible for cholesterol biosynthesis and the
formation of the intermediate metabolites geranylgeranylpyrophosphate (GGPP) and …

Simvastatin increases temozolomide‐induced cell death by targeting the fusion of autophagosomes and lysosomes

…, E Samiei, M Aghaei, LK Cole, J Alizadeh… - The FEBS …, 2020 - Wiley Online Library
Temozolomide (TMZ) is a chemotherapy agent used to treat Grade IV astrocytoma, also
known as glioblastoma (GBM). TMZ treatment causes DNA damage that results in tumor cell …

[HTML][HTML] Autophagy, apoptosis, the unfolded protein response, and lung function in idiopathic pulmonary fibrosis

P Sharma, J Alizadeh, M Juarez, A Samali, AJ Halayko… - Cells, 2021 - mdpi.com
Autophagy, apoptosis, and the unfolded protein response (UPR) are fundamental biological
processes essential for manifold cellular functions in health and disease. Idiopathic …