Eukaryotic cells contain assemblies of RNAs and proteins termed RNA granules. Many proteins
within these bodies contain KH or RRM RNA-binding domains as well as low complexity …

Bone marrow transplantation is the primary therapy for numerous hematopoietic disorders.
The efficiency of bone marrow transplantation depends on the function of long-term …

The experiments reported here document that the tumor suppressor retinoblastoma protein (pRB)
plays an important role in the production and maintenance of the terminally …

Background— The clinical use of doxorubicin is limited by cardiotoxicity. Histopathological
changes include interstitial myocardial fibrosis and the appearance of vacuolated …

The terminal differentiation of mammalian muscle cells requires the tumor suppressor
retinoblastoma protein (Rb). Unlike their wild-type counterparts, multinucleated myotubes from …

Genome editing with CRISPR/Cas9 is a promising new approach for correcting or mitigating
disease-causing mutations. Duchenne muscular dystrophy (DMD) is associated with lethal …

Muscle enhancer factor-2A (MEF2A), a member of the MADS family, induced myogenic
development when ectopically expressed in clones of nonmuscle cells of human clones, a …

We probed an epigenetic regulatory path from small molecule to neuronal gene activation.
Isoxazole small molecules triggered robust neuronal differentiation in adult neural stem cells, …

Rationale: Transgenic Notch reporter mice express enhanced green fluorescent protein in
cells with C-promoter binding factor-1 response element transcriptional activity (CBF1-RE x4 -…

Myocardin-related transcription factors (MRTFs) regulate cellular contractility and motility by
associating with serum response factor (SRF) and activating genes involved in cytoskeletal …