Maresin 1 biosynthesis during platelet–neutrophil interactions is organ-protective

REE Abdulnour, J Dalli, JK Colby… - Proceedings of the …, 2014 - National Acad Sciences
Unregulated acute inflammation can lead to collateral tissue injury in vital organs, such as
the lung during the acute respiratory distress syndrome. In response to tissue injury, …

Human mesenchymal stem (stromal) cells promote the resolution of acute lung injury in part through lipoxin A4

X Fang, J Abbott, L Cheng, JK Colby… - The Journal of …, 2015 - journals.aai.org
Previous studies demonstrated that bone marrow–derived mesenchymal stem (stromal)
cells (MSCs) reduce the severity of acute lung injury in animal models and in an ex vivo …

[HTML][HTML] Dicer inactivation in osteoprogenitor cells compromises fetal survival and bone formation, while excision in differentiated osteoblasts increases bone mass in …

…, S Hussain, R Mudhasani, I Parulkar, JL Colby… - Developmental …, 2010 - Elsevier
MicroRNA attenuation of protein translation has emerged as an important regulator of
mesenchymal cell differentiation into the osteoblast lineage. A compelling question is the extent to …

[HTML][HTML] The role of PPAR-δ in metabolism, inflammation, and cancer: many characters of a critical transcription factor

Y Liu, JK Colby, X Zuo, J Jaoude, D Wei… - International journal of …, 2018 - mdpi.com
Peroxisome proliferator-activated receptor-delta (PPAR-δ), one of three members of the PPAR
group in the nuclear receptor superfamily, is a ligand-activated transcription factor. PPAR-…

[HTML][HTML] Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ

…, D Li, H Wang, LA Valentin, JK Colby… - Nature …, 2022 - nature.com
Pancreatic intraepithelial neoplasia (PanIN) is a precursor of pancreatic ductal adenocarcinoma
(PDAC), which commonly occurs in the general populations with aging. Although most …

Comparison of information-dependent acquisition on a tandem quadrupole TOF vs a triple quadrupole linear ion trap mass spectrometer for broad-spectrum drug …

KL Thoren, JM Colby, SB Shugarts, AHB Wu… - Clinical …, 2016 - academic.oup.com
BACKGROUND Liquid chromatography high-resolution mass spectrometry (LC-HRMS)
with untargeted data collection is especially attractive for general unknown drug screening …

The SWI/SNF ATPases are required for triple negative breast cancer cell proliferation

…, S Douthwright, G Browne, JL Colby… - Journal of cellular …, 2015 - Wiley Online Library
The Brahma (BRM) and Brahma‐related Gene 1 (BRG1) ATPases are highly conserved
homologs that catalyze the chromatin remodeling functions of the multi‐subunit human SWI/…

15-epi-Lipoxin A4, Resolvin D2, and Resolvin D3 induce NF-κB regulators in bacterial pneumonia

…, I Barkas, S Benito-Figueroa, JK Colby… - The Journal of …, 2018 - journals.aai.org
Specialized proresolving mediators (SPMs) decrease NF-κB activity to prevent excessive
tissue damage and promote the resolution of acute inflammation. Mechanisms for NF-κB …

[HTML][HTML] Low hemoglobin increases risk for cerebrovascular disease, kidney disease, pulmonary vasculopathy, and mortality in sickle cell disease: A systematic …

KI Ataga, VR Gordeuk, I Agodoa, JA Colby, K Gittings… - PLoS …, 2020 - journals.plos.org
Sickle cell disease (SCD) is characterized by deoxygenation–induced polymerization of
hemoglobin in red blood cells, leading to hemolytic anemia, vaso–occlusion, and the …

[HTML][HTML] Efficacy and safety of omalizumab in children and adolescents with moderate-to-severe asthma: a systematic literature review

J Corren, A Kavati, B Ortiz, JA Colby… - Allergy and Asthma …, 2017 - ingentaconnect.com
Background: There are limited pediatric data about the use of omalizumab, especially the
effectiveness and safety of omalizumab in the real-world management of allergic asthma. …