Worldwide prevalence of childhood obesity has increased greatly during the past three
decades. The increasing occurrence in children of disorders such as type 2 diabetes is believed …

The neurotrophin brain-derived neurotrophic factor (BDNF) inhibits food intake, and rodent
models of BDNF disruption all exhibit increased food intake and obesity, as well as …

Context: Some studies suggest the presence of metabolic syndrome before adulthood may
identify those at high risk for later cardiovascular morbidity, but there are few data examining …

The concentration of tris(2-carboxyethyl)phosphine (TCEP) can be conveniently determined
by measuring the amount of 2-nitro-5-thiobenzoate (NTB) formed after reaction with 5,5′-…

Background Brain-derived neurotrophic factor (BDNF) has been found to be important in
energy homeostasis in animal models, but little is known about its role in energy balance in …

Background Children with rs9939609 FTO variant alleles (homozygous = AA and heterozygous
= AT) are predisposed to greater adiposity than are those with 2 wild-type alleles (TT). …

Neurodevelopmental disorders have a heritable component and are associated with region
specific alterations in brain anatomy. However, it is unclear how genetic risks for …

Objective: Bardet-Biedl syndrome (BBS) is a genetically heterogeneous disorder of the
primary cilium associated with obesity. In BBS mouse models, ciliary dysfunction leads to …

As an active interface between the host and their diet, the gut microbiota influences host
metabolic adaptation; however, the contributions of fungi have been overlooked. Here, we …

We report on a patient with trisomy 21, microophthalmia, neonatal diabetes mellitus,
hypopituitarism, and a complex structural brain anomaly who was a member of a large bilineal …