RECENTLY Zhang et al. cloned a gene that is expressed only in adipose tissue of the mouse.
The obese phenotype of the ob/ob mouse is linked to a mutation in the obese gene that …

We investigated non‐alcoholic fatty liver disease ( NAFLD ) prevalence and its metabolic
associations in patients with type 1 diabetes ( T1D ), and in insulin‐naïve and insulin‐treated …

OBJECTIVE Basal insulin Fc (BIF) (insulin efsitora alfa; LY3209590), a fusion protein combining
a novel single-chain insulin variant with a human IgG Fc domain, is designed for once-…

OBJECTIVE Basal Insulin Fc (BIF; insulin efsitora alfa; LY3209590), a fusion protein combining
a novel single-chain insulin variant with a human IgG Fc domain, is designed for once-…

URLi is a novel prandial insulin lispro formulation developed to more closely match physiological
insulin secretion. This phase 3, 26-week trial evaluated the efficacy and safety of URLi …

Data on cytokeratin-18 (K-18) and enhanced liver fibrosis (ELF) score in insulin-treated
diabetes patients with non-alcoholic fatty liver disease (NAFLD) are limited. This study analyzed …

Background URLi is a novel prandial insulin lispro formulation developed to more closely
match physiological insulin secretion. This randomized, double-blind, 4-period, crossover study…

B asal I nsulin F c (BIF; LY3209590), a fusion protein combining a novel single-chain insulin
variant with a human IgG Fc domain, is designed for QW administration. This randomized, …

Ambulatory glucose profiles were evaluated in 269 (22%) patients (pts) in PRONTO-T1D
assigned to double-blind URLi (n= 97) or lispro (n= 99) given at start of the meal, or open-label …

The safety population from 3 randomized, open-label, phase 2 treat-to-target studies included
942 people with T2D previously treated with basal insulin (T2D-Switch) or new to insulin …