[HTML][HTML] Genetic and pharmacologic inactivation of ANGPTL3 and cardiovascular disease

…, WHH Sheu, IT Lee, KW Liang… - … England Journal of …, 2017 - Mass Medical Soc
Background Loss-of-function variants in the angiopoietin-like 3 gene (ANGPTL3) have been
associated with decreased plasma levels of triglycerides, low-density lipoprotein (LDL) …

Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease

…, JW Jukema, N Sattar, R Smit, RH Chung, KW Liang… - Nature …, 2017 - nature.com
To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease
(CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both …

Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride …

…, IT Lee, SJ Lee, WJ Lee, KW Liang… - Human molecular …, 2017 - academic.oup.com
Large-scale meta-analyses of genome-wide association studies (GWAS) have identified >175
loci associated with fasting cholesterol levels, including total cholesterol (TC), high-…

Berberine inhibits platelet-derived growth factor-induced growth and migration partly through an AMPK-dependent pathway in vascular smooth muscle cells

KW Liang, SC Yin, CT Ting, SJ Lin, CM Hsueh… - European journal of …, 2008 - Elsevier
Platelet-derived growth factor (PDGF) is released from vascular smooth muscle cells (VSMCs),
endothelial cells, or macrophages after percutaneous coronary intervention and is related …

Berberine suppresses MEK/ERK-dependent Egr-1 signaling pathway and inhibits vascular smooth muscle cell regrowth after in vitro mechanical injury

KW Liang, CT Ting, SC Yin, YT Chen, SJ Lin… - Biochemical …, 2006 - Elsevier
Vascular smooth muscle cell (SMC) proliferation plays an important role in the pathogenesis
of atherosclerosis and post-angioplasty restenosis. Berberine is a well-known component of …

Association between serum adipsin levels and insulin resistance in subjects with various degrees of glucose intolerance

…, IT Lee, SY Lin, WL Lee, KW Liang… - Journal of the …, 2019 - academic.oup.com
Context The association between adipsin and glucose metabolism in human subjects
remains unclear. Objective We investigated the associations between adipsin and insulin …

[HTML][HTML] Lower all-cause mortality for coronary heart or stroke patients who adhere better to mediterranean diet-An NHANES Analysis

KW Liang, CL Lee, WJ Liu - Nutrients, 2022 - mdpi.com
Consuming a Mediterranean-style diet (MED) is helpful for primary prevention of atherosclerotic
cardiovascular disease (ASCVD). However, few studies have compared mortality in …

Coronary severity score and C-reactive protein predict major adverse cardiovascular events in patients with stable coronary artery disease (from the Taichung CAD …

…, YC Liao, KY Wang, IT Lee, JS Wang, KW Liang - Clinica Chimica …, 2015 - Elsevier
Background Whether angiographic coronary severity really predicts future major adverse
cardiovascular events (MACEs) in patients with coronary artery disease (CAD) is uncertain. …

Aryl hydrocarbon receptor deficiency attenuates oxidative stress-related mesangial cell activation and macrophage infiltration and extracellular matrix accumulation in …

…, SH Liu, CK Chiang, SY Lin, KW Liang… - Antioxidants & redox …, 2016 - liebertpub.com
Aims: Activation of glomerular mesangial cells (MCs) and functional changes of renal tubular
cells are due to metabolic abnormalities, oxidative stress, and matrix accumulation in the …

MRI measured epicardial adipose tissue thickness at the right AV groove differentiates inflammatory status in obese men with metabolic syndrome

KW Liang, IC Tsai, WJ Lee, IT Lee, WL Lee, SY Lin… - …, 2012 - Wiley Online Library
Epicardial adipose tissue (EAT) is a metabolically active visceral fat, which secretes inflammatory
cytokines and adipokines. In this study, our aim was to examine which measurements …