[HTML][HTML] Immunotherapy in Non-Small Cell Lung Cancer With Actionable Mutations Other Than EGFR

K Seegobin, U Majeed, N Wiest, R Manochakian… - Frontiers in …, 2021 - frontiersin.org
While first line targeted therapies are the current standard of care treatment for non-small
cell lung cancer (NSCLC) with actionable mutations, the cancer cells inevitably acquire …

[HTML][HTML] Genomic landscape of lung adenocarcinomas in different races

H Shi, K Seegobin, F Heng, K Zhou, R Chen… - Frontiers in …, 2022 - frontiersin.org
Background: Lung adenocarcinoma is a molecularly heterogeneous disease. Several
studies, including The Cancer Genome Atlas Research Network (TCGA) and Lung Cancer …

[HTML][HTML] Role of immune checkpoint inhibitor therapy in advanced EGFR-mutant non-small cell lung cancer

N Wiest, U Majeed, K Seegobin, Y Zhao, Y Lou… - Frontiers in …, 2021 - frontiersin.org
Over the last decade, the treatment of advanced non-small cell lung cancer (NSCLC) has
undergone rapid changes with innovations in oncogene-directed therapy and immune …

A case of worsening pulmonary arterial hypertension and pleural effusions by bosutinib after prior treatment with dasatinib

K Seegobin, A Babbar, J Ferreira… - Pulmonary …, 2017 - journals.sagepub.com
A 52-year-old man with a past medical history of chronic myeloid leukemia (CML) in remission
developed progressive shortness of breath over a two-month period. He was initially …

Severe beta blocker and calcium channel blocker overdose: Role of high dose insulin

K Seegobin, S Maharaj, A Deosaran… - The American Journal of …, 2018 - Elsevier
A 54-year-old female presented after taking an overdose of an unknown amount of
hydrochlorothiazide, doxazocin, atenolol and amlodipine. She was initially refractory to treatment …

Letrozole-induced hepatitis with autoimmune features: a rare adverse drug reaction with review of the relevant literature

B Gharia, K Seegobin, S Maharaj… - Oxford Medical Case …, 2017 - academic.oup.com
While aromatase inhibitors (AIs) have been known to cause minor elevations in liver enzymes,
severe hepatotoxicity is rare. To the best of our knowledge, this is the first reported case of …

[HTML][HTML] Necrotizing Pseudomonas aeruginosa Community-Acquired Pneumonia: A Case Report and Review of the Literature

S Maharaj, C Isache, K Seegobin, S Chang… - Case reports in …, 2017 - hindawi.com
Lung cavities are not typically associated with community-acquired pneumonia (CAP). CAP
due to P. aeruginosa is rare and even less commonly causes necrotizing pneumonia. We …

Clinical characteristics, prognostic indicators, and survival outcomes in intravascular lymphoma: Mayo Clinic experience (2003–2018)

K Seegobin, Z Li, M Alhaj Moustafa… - American journal of …, 2022 - Wiley Online Library
Intravascular lymphoma (IVL) is a rare extranodal non‐Hodgkin lymphoma. We performed a
retrospective analysis of 55 IVL patients who were treated at our institution 2003–2018. …

[HTML][HTML] Severe carvedilol toxicity without overdose–caution in cirrhosis

S Maharaj, K Seegobin, J Perez-Downes, B Bajric… - Clinical …, 2017 - Springer
Background Carvedilol is used in the management of hypertension, ischemic heart disease,
heart failure and most recently, portal hypertension. It has been associated with improved …

Increased risk of arterial thromboembolic events with combination lenalidomide/dexamethasone therapy for multiple myeloma

S Maharaj, S Chang, K Seegobin… - Expert Review of …, 2017 - Taylor & Francis
Introduction: Cancer associated thrombosis is a leading cause of morbidity and mortality.
Research and guidelines have focused on venous thromboembolic events (VTE). Within the …