Background and objective: Previous studies have indicated a high incidence of lung cancer
in IPF, and some have identified its risk factors. However, those studies were retrospective …

BACKGROUND: Indoleamine 2,3-dioxygenase (IDO) catalyzes the rate-limiting step of
tryptophan (Trp) degradation along the kynurenine (Kyn) pathway. By depleting tryptophan, IDO …

BACKGROUND: Acute exacerbation (AE) is currently established as a distinct condition
with acute deterioration of respiratory status in idiopathic pulmonary fibrosis (IPF). Recently, …

A randomised, double-blind, phase II, dose escalation trial was conducted to assess the
safety, tolerability and pharmacokinetics of the tyrosine kinase inhibitor nintedanib, alone and …

Purpose: To compare the performance of apparent diffusion coefficient (ADC) with that of
signal intensity of the lesion-to–spinal cord ratio (LSR) in differentiating lung cancer from …

OBJECTIVE: To assess the difference in clinical features and prognosis of patients with
interstitial lung disease (ILD) comparing polymyositis (PM) and dermatomyositis (DM). METHODS…

Peroxisome proliferator–activated receptor γ (PPARγ) is a ligand-activated transcriptional
factor belonging to the nuclear receptor superfamily. PPARγ, which is predominantly …

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease of
unknown etiology. Environmental factors, especially occupational agents, may be of great …

The aim of the present study was to clarify the clinical characteristics and prognosis of
patients with interstitial lung disease (ILD) associated with amyopathic dermatomyositis (ILD-ADM)…

Interstitial lung disease (ILD) associated with polymyositis/dermatomyositis (ILD-PM/DM),
including amyopathic dermatomyositis (ADM), is recognized as an important condition …