Background Contemporary data for causes of vision impairment and blindness form an
important basis of recommendations in public health policies. Refreshment of the Global Vision …

Background Global and regional prevalence estimates for blindness and vision impairment
are important for the development of public health policies. We aimed to provide global …

… Zawalich WS, Zawalich KC, Shulman Gl, Rossetti L: Chronic in vivo hyperglycemia impairs
phosphoinositide hydrolysis and insulin release in isolated perfused rat islets. Endocrinology …

Increased plasma FFA reduce insulin-stimulated glucose uptake. The mechanisms responsible
for this inhibition, however, remain uncertain. It was the aim of this study to determine …

Background To contribute to the WHO initiative, VISION 2020: The Right to Sight, an
assessment of global vision impairment in 2020 and temporal change is needed. We aimed to …

The hexosamine pathway has been implicated in the pathogenesis of diabetic complications.
We determined first that hyperglycemia induced a decrease in glyceraldehyde-3-…

Intraperitoneal injection of purified recombinant Acrp30 lowers glucose levels in mice. To
gain insight into the mechanism(s) of this hypoglycemic effect, purified recombinant Acrp30 …

Leptin, the protein encoded by the obese (ob) gene, is synthesized and released in response
to increased energy storage in adipose tissue 1 , 2 , 3 , 4 . However, it is still not known …

Circulating insulin inhibits endogenous glucose production. Here we report that bidirectional
changes in hypothalamic insulin signaling affect glucose production. The infusion of either …

Glucagon, the counter-regulatory hormone to insulin, is secreted from pancreatic α cells in
response to low blood glucose. To examine the role of glucagon in glucose homeostasis, …