Guanine nucleotide exchange factors (GEFs) that promote GTP loading onto the guanosine
triphosphatases (GTPases) Rho and Rac are prominent players in cancer progression. …

The growth factor heregulin (HRG), a ligand of ErbB3 and ErbB4 receptors, contributes to
breast cancer development and the promotion of metastatic disease, and its expression in …

Background: Alcohol dependence (AD) vulnerability is determined by a complex array of
genetic factors. Given the potential role of endocannabinoid system in AD, polymorphisms …

Guanine nucleotide Exchange Factors (GEFs) are responsible for mediating GDP/GTP
exchange for specific small G proteins, such as Rac. There has been substantial evidence for the …

Introduction The Rac-GEF P-REX1 is a key mediator of ErbB signaling in breast cancer
recently implicated in mammary tumorigenesis and metastatic dissemination. Although P-REX1 …

Overexpression of PKCϵ, a kinase associated with tumor aggressiveness and widely implicated
in malignant transformation and metastasis, is a hallmark of multiple cancers, including …

ZEB1 is a master regulator of the Epithelial-to-Mesenchymal Transition (EMT) program. While
extensive evidence confirmed the importance of ZEB1 as an EMT transcription factor that …

Diacylglycerol (DAG)/phorbol ester-regulated protein kinase C (PKC) isozymes have been
widely linked to tumor promotion and the development of a metastatic phenotype. PKCε, an …

β2-chimaerin is a Rac1-specific negative regulator and a candidate tumor suppressor in
breast cancer but its precise function in mammary tumorigenesis in vivo is unknown. Here, we …

Chimaerins are a family of diacylglycerol- and phorbol ester-regulated GTPase activating
proteins (GAPs) for the small G-protein Rac. Extensive evidence indicates that these proteins …