Growth factors synthesized and released by target tissues promote survival and differentiation
of innervating neurons. This retrograde signal begins when growth factors bind receptors …

Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder characterized by increased
incidence of benign and malignant tumors of neural crest origin. Mutations that activate …

The mechanisms underlying neuronal ischemic preconditioning, a phenomenon in which brief
episodes of ischemia protect against the lethal effects of subsequent periods of prolonged …

Although significant improvements have been made in the outcomes of children with cancer,
the pace of improvement has slowed in recent years as the limits of therapy intensification …

The neurotrophin family of growth factors supports survival and differentiation of neurons in
the developing vertebrate nervous system by binding activating receptor tyrosine kinases, …

The wide variety of clinical manifestations of the genetic syndrome neurofibromatosis type 1
(NF1) are driven by overactivation of the RAS pathway. Mitogen-activated protein kinase …

… Klesse, MD, PhD, 8 Sarah Leary, MD, 23 Javad Nazarian, PhD, 24 Marcel Kool, PhD, 25
Pieter Wesseling, MD, 26 Marina Ryzhova, MD, 27 Olga Zheludkova, MD, 28 Andrey V …

Neurofibromatosis type 1 (NF1) clinical care is on the cusp of a transformative shift. With the
success of recent clinical trials using MEK inhibitors, an increasing number of NF1 patients …

Objective: To assess the efficacy of lovastatin on visuospatial learning and attention for treating
cognitive and behavioral deficits in children with neurofibromatosis type 1 (NF1). Methods…

TrkA, the high affinity receptor for nerve growth factor (NGF), is essential for the development
of nociceptive sensory and sympathetic neurons. The zinc finger transcription factor Klf7 …