Functional characterization of signaling pathways that critically control mantle cell lymphoma
(MCL) cell growth and survival is relevant to designing new therapies for this lymphoma. …

Purpose: Colorectal cancer (CRC) is one of the most common cancers in western countries.
Identification of circulating markers for CRC would optimize early stage diagnosis and the …

Transformation of primary B lymphocytes by Epstein-Barr virus requires the establishment of
a strictly latent infection, the expression of several latent viral proteins, and sustained …

Albumin re-uptake is a receptor-mediated pathway located in renal proximal tubuli. There is
increasing evidence of glomerular protein handling by podocytes, but little is known about …

SerpinB3 has been recently described as an early marker of liver carcinogenesis, but the
potential mechanistic role of this serpin in tumor development is still poorly understood. …

Dent disease (DD), an X-linked renal tubulopathy, is mainly caused by loss-of-function
mutations in CLCN5 (DD1) and OCRL genes. CLCN5 encodes the ClC-5 antiporter that in …

Patients infected with human immunodeficiency virus type 1 (HIV-1) develop a spectrum of
B cell lymphoproliferative disorders ranging from polyclonal B cell activation to B cell …

Transformation of primary B lymphocytes by Epstein‐Barr Virus (EBV) requires the
establishment of a latent infection, the expression of several latent viral proteins and a sustained …

Colorectal cancer is characterized by aberrant Cyclooxigenase-2 (COX-2) and β-Catenin
pathways. Recently, the protease inhibitor SerpinB3 has been described overexpressed in …

Background In the setting of liver injury hepatic progenitor cells are activated, counterbalancing
the inhibited regenerative capacity of mature hepatocytes. Chronic activation of this …