Previous studies in this laboratory established that low density lipoprotein (LDL) incubated
with cultured endothelial cells, smooth muscle cells, or macrophages undergoes free radical-…

Oxidatively modified low-density lipoprotein (LDL), generated as a result of incubation of
LDL with specific cells (eg, endothelial cells, EC) or redox metals like copper, has been …

Mutations in the nuclear envelope proteins lamins A and C cause a broad variety of human
diseases, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, and …

The triglycerides in chylomicrons are hydrolyzed by lipoprotein lipase (LpL) along the
luminal surface of the capillaries. However, the endothelial cell molecule that facilitates …

The lipolytic processing of triglyceride-rich lipoproteins by lipoprotein lipase (LPL) is the
central event in plasma lipid metabolism, providing lipids for storage in adipose tissue and fuel …

Progerias are rare genetic diseases characterized by premature aging. Several progeroid
disorders are caused by mutations that lead to the accumulation of a lipid-modified (…

Hutchinson–Gilford progeria syndrome (HGPS), a progeroid syndrome in children, is caused
by mutations in LMNA (the gene for prelamin A and lamin C) that result in the deletion of 50 …

Hutchinson-Gilford progeria syndrome (HGPS) is caused by the production of a truncated
prelamin A, called progerin, which is farnesylated at its carboxyl terminus. Progerin is targeted …

Defects in the biogenesis of lamin A from its farnesylated precursor, prelamin A, lead to the
accumulation of prelamin A at the nuclear envelope, cause misshapen nuclei, and result in …

The main function of the nuclear lamina, an intermediate filament meshwork lying primarily
beneath the inner nuclear membrane, is to provide structural scaffolding for the cell nucleus. …