Type 2 diabetes (T2D) is caused by insufficient insulin secretion from pancreatic β cells. To
identify candidate genes contributing to T2D pathophysiology, we studied human pancreatic …

Mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) is a mitochondrial-derived
peptide that attenuates weight gain and hyperinsulinemia when administered to high fat-fed …

The amplification of glucose-stimulated insulin secretion (GSIS) through incretin signaling is
critical for maintaining physiological glucose levels. Incretins, like glucagon-like peptide 1 (…

Background/Aims: To evaluate the association between allelic variants of melanocortin
receptors -3 and -4 (MC3R and MC4R, respectively) and leptin receptor (LEPR) genes with body …

Aims Reduced expression of exocytotic genes is associated with functional defects in insulin
exocytosis contributing to impaired insulin secretion and type 2 diabetes (T2D) development…

Aims Pancreatic β-cells synthesize and release serotonin (5 hydroxytryptamine, 5HT);
however, the role of 5HT receptors on glucose stimulated insulin secretion (GSIS) and the …

Endothelin-converting enzyme-1c (ECE-1c) is a membrane metalloprotease involved in
endothelin-1 synthesis, which has been shown in vitro to have a role in breast, ovary and …

Objective Ependymin-Related Protein 1 (EPDR1) was recently identified as a secreted
human batokine regulating mitochondrial respiration linked to thermogenesis in brown fat. …

Methylation in CpG sites of the PPARGC1A gene (encoding PGC1-α) has been associated
with adiposity, insulin secretion/sensitivity indexes and type 2 diabetes. We assessed the …

We previously reported that loss of mitochondrial transcription factor B1 (TFB1M) leads to
mitochondrial dysfunction and is involved in the pathogenesis of type 2 diabetes (T2D). …