User profiles for Lutian Yao

Lutian Yao

China Medical University/UPenn
Verified email at cmu.edu.cn
Cited by 1933

[HTML][HTML] (−)-Epigallocatechin-3-Gallate Ameliorates Learning and Memory Deficits by Adjusting the Balance of TrkA/p75NTR Signaling in APP/PS1 Transgenic Mice

…, L Sha, S Wang, L Tao, L Yao, M He, Z Yao… - Molecular …, 2014 - Springer
Alzheimer's disease (AD) is pathologically characterized by deposition of β-amyloid (Aβ)
peptides, which closely correlates with the balance of nerve growth factor (NGF)-related TrkA/…

Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment

L Zhong, L Yao, RJ Tower, Y Wei, Z Miao, J Park… - Elife, 2020 - elifesciences.org
Bone marrow mesenchymal lineage cells are a heterogeneous cell population involved in
bone homeostasis and diseases such as osteoporosis. While it is long postulated that they …

Marrow adipogenic lineage precursor: A new cellular component of marrow adipose tissue

L Zhong, L Yao, P Seale, L Qin - Best Practice & Research Clinical …, 2021 - Elsevier
Bone marrow mesenchymal stromal cells are a highly heterogenic cell population containing
mesenchymal stem cells as well as other cell types. With the advance of single cell …

FLASH proton radiotherapy spares normal epithelial and mesenchymal tissues while preserving sarcoma response

…, K Shoniyozov, J Chiango, M Cerullo, K Varner, L Yao… - Cancer research, 2021 - AACR
These findings will spur investigation of FLASH radiotherapy in sarcoma and additional cancers
where mesenchymal tissues are at risk, including head and neck cancer, breast cancer, …

[HTML][HTML] Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss

W Yu, L Zhong, L Yao, Y Wei, T Gui, Z Li… - The Journal of …, 2021 - Am Soc Clin Investig
Bone is maintained by coupled activities of bone-forming osteoblasts/osteocytes and bone-resorbing
osteoclasts. Alterations in this relationship can lead to pathologic bone loss such …

Targeting cartilage EGFR pathway for osteoarthritis treatment

Y Wei, L Luo, T Gui, F Yu, L Yan, L Yao… - Science translational …, 2021 - science.org
Osteoarthritis (OA) is a widespread joint disease for which there are no disease-modifying
treatments. Previously, we found that mice with cartilage-specific epidermal growth factor …

SOX9 keeps growth plates and articular cartilage healthy by inhibiting chondrocyte dedifferentiation/osteoblastic redifferentiation

…, D Rux, RJ Tower, L Yao… - Proceedings of the …, 2021 - National Acad Sciences
Cartilage is essential throughout vertebrate life. It starts developing in embryos when
osteochondroprogenitor cells commit to chondrogenesis, activate a pancartilaginous program to …

[HTML][HTML] The mediating role of self-efficacy in the relationship between Big five personality and depressive symptoms among Chinese unemployed population: a cross …

Y Wang, L Yao, L Liu, X Yang, H Wu, J Wang, L Wang - BMC psychiatry, 2014 - Springer
Background Besides the rapid growth of economy, unemployment becomes a severe socio-economic
problem in China. The huge population base in China makes the unemployed …

Superoxide dismutase-loaded porous polymersomes as highly efficient antioxidant nanoparticles targeting synovium for osteoarthritis therapy

T Gui, L Luo, B Chhay, L Zhong, Y Wei, L Yao, W Yu… - Biomaterials, 2022 - Elsevier
… Tao Gui and Lutian Yao performed the histology and imaging analysis. Charles L Nelson
provided human joint tissues and assisted histology analysis. Lijun Luo and Leilei Zhong …

[HTML][HTML] Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer

Z Niu, M Wang, L Zhou, L Yao, Q Liao, Y Zhao - Scientific reports, 2015 - nature.com
Glucose-regulated protein 78 (GRP78) is a member of the heat-shock protein 70 family. We
evaluated the expression of GRP78 using tissue microarray-based immunohistochemistry in …