[HTML][HTML] Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: implications to mitochondria-targeted antioxidant …

…, MJ Calkins, AP Reddy, P Mao, M Manczak - … et Biophysica Acta (BBA …, 2012 - Elsevier
Synaptic pathology and mitochondrial oxidative damage are early events in Alzheimer's
disease (AD) progression. Loss of synapses and synaptic damage are the best correlates of …

Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases

PH Reddy, TP Reddy, M Manczak, MJ Calkins… - Brain research …, 2011 - Elsevier
The purpose of this article is to review the recent developments of abnormal mitochondrial
dynamics, mitochondrial fragmentation, and neuronal damage in neurodegenerative diseases…

Protective effects of Indian spice curcumin against amyloid-β in Alzheimer's disease

PH Reddy, M Manczak, X Yin… - Journal of …, 2018 - content.iospress.com
The purpose of our article is to assess the current understanding of Indian spice, curcumin,
against amyloid-ß (Aß)-induced toxicity in Alzheimer’s disease (AD) pathogenesis. Natural …

Mitochondria are a direct site of Aβ accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease …

M Manczak, TS Anekonda, E Henson… - Human molecular …, 2006 - academic.oup.com
… , phophsoramidon and leupeptin; 0.5 mm PMSF; and 1 mm EGTA). Samples were sonicated
… The extract was neutralized with 0.25 m Tris (pH 8.0) containing 30% acetonitrile and 5 m

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease …

M Manczak, MJ Calkins, PH Reddy - Human molecular genetics, 2011 - academic.oup.com
The purpose of our study was to better understand the relationship between mitochondrial
structural proteins, particularly dynamin-related protein 1 (Drp1) and amyloid beta (Aβ) in the …

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of …

MJ Calkins, M Manczak, P Mao… - Human molecular …, 2011 - academic.oup.com
… Briefly, cells were scraped from six-well plates into a homogenization buffer containing 280
mm sucrose, 10 mm Tris, pH 7.4, and 1 mm EDTA. Then the whole lysate was centrifuged at …

Mitochondria-targeted antioxidants protect against amyloid-β toxicity in Alzheimer's disease neurons

M Manczak, P Mao, MJ Calkins… - Journal of …, 2010 - content.iospress.com
The purpose of our study was to investigate the effects of the mitochondria-targeted antioxidants,
MitoQ and SS31, and the anti-aging agent resveratrol on neurons from a mouse model (…

Determination of information flow direction among brain structures by a modified directed transfer function (dDTF) method

A Korzeniewska, M Mańczak, M Kamiński… - Journal of neuroscience …, 2003 - Elsevier
A modification of directed transfer function—direct DTF—is proposed for the analysis of
direct information transfer among brain structures on the basis of local field potentials (LFP). …

Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage

U Shirendeb, AP Reddy, M Manczak… - Human molecular …, 2011 - academic.oup.com
The purpose of our study was to determine the relationship between mutant huntingtin (Htt)
and mitochondrial dynamics in the progression of Huntington's disease (HD). We measured …

Differential expression of oxidative phosphorylation genes in patients with Alzheimer's disease: implications for early mitochondrial dysfunction and oxidative damage

M Manczak, BS Park, Y Jung, PH Reddy - Neuromolecular medicine, 2004 - Springer
In Alzheimer’s disease (AD) pathogenesis, increasing evidence implicates mitochondrial
dysfunction resulting from molecular defects in oxidative phosphorylation (OXPHOS). The …