Pharmacogenetics is the study of the linkage between an individual’s genotype and that
individual’s ability to metabolize a foreign compound. Differences in metabolism of therapeutics …

The measurement and characterization of circulating tumor cells (CTCs) hold promise for
advancing personalized therapeutics. CTCs are the precursor to metastatic cancer and thus …

Therapeutic drug monitoring (TDM) for certain tricyclic antidepressants (TCAs) and lithium is
supported on the basis of clearly defined therapeutic ranges. TDM is of particular …

… Mark W Linder Mark W Linder … Yusheng Zhu, Michael Shennan, Kristen K Reynolds, Nancy
A Johnson, Matthew R Herrnberger, Roland Valdes, Mark W Linder, Estimation of Warfarin …

… grams together with low-molecular-weight heparin for outpatient treatment of acute venous
… Linder MW. Genetic mechanisms for hypersensitivity and resistance to the anticoagulant …

Background: The dose response relationship of warfarin is unpredictable. Polymorphism of
the Cytochrome P4502C9 enzyme leads to warfarin hypersensitivity presumably due to …

Warfarin is the most commonly prescribed oral anticoagulant for the treatment and prevention
of thromboembolic events. The correct maintenance dose of warfarin for a given patient is …

The use of multiple medications is growing at an alarming rate with some reports documenting
an average of 12–22 prescriptions being used by individuals ≥50 years of age. The …

We performed a randomised pilot trial of PerMIT, a novel decision support tool for genotype-based
warfarin initiation and maintenance dosing, to assess its efficacy for improving …

The development and performance of molecular genetic assays has required increasingly
complex quality assurance in recent years and continues to pose new challenges. Quality …